Abstract

This study accessed the multiple drug resistance patterns of Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli isolated from the urine of pregnant women and HIV patients in Port Harcourt, Nigeria. A total of two hundred and sixty (260) urine specimen were gotten from pregnant women (130) and HIV patients (130). These specimens were examined for the presence and isolation of Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli with the use of cystine lactose electrolyte deficient agar (CLED) media. In addition, antibiotic susceptibility test was carried out and MAR index for each uropathogen was determined. Results showed Klebsiella pneumoniae and Escherichia coli as the highest occurring uropathogens in pregnant women and HIV patients respectively. All uropathogens from both groups were highly resistant to Amoxicillin and Imipenem and highly susceptible to Ofloxacin and Levofloxacin. Furthermore, there is a high level of multiple drug resistance exhibited by these uropathogens with Pseudomonas aeruginosa having 10.0% of the isolate at MAR index of 1. There is therefore the urgent need to control the indiscriminate use of antibiotics, as this will help restore the susceptibility of microbe to antibiotics.